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  • Title: Interaction of colchicine with human serum albumin investigated by spectroscopic methods.
    Author: Hu YJ, Liu Y, Zhao RM, Qu SS.
    Journal: Int J Biol Macromol; 2005 Nov 15; 37(3):122-6. PubMed ID: 16239027.
    Abstract:
    We investigated the interaction between colchicine and human serum albumin (HSA) by fluorescence and UV-vis absorption spectroscopy. In the mechanism discussion, it was proved that the fluorescence quenching of HSA by colchicine is a result of the formation of colchicines-HSA complex; van der Waals interactions and hydrogen bonds play a major role in stabilizing the complex. The modified Stern-Volmer quenching constant K(a) and corresponding thermodynamic parameters deltaH, deltaG, deltaS at different temperatures were calculated. The distance r between donor (Trp214) and acceptor (colchicine) was obtained according to fluorescence resonance energy transfer (FRET).
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