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  • Title: The nematode death machine in 3D.
    Author: Pop C, Salvesen GS.
    Journal: Cell; 2005 Oct 21; 123(2):192-3. PubMed ID: 16239138.
    Abstract:
    Regulated apoptosis is part of the development of the nematode Caenorhabditis elegans. In a recent paper in Nature, Yan et al. (2005) describe the in vitro reconstitution of the core components of the worm apoptotic pathway. Based on a structural analysis of the complex between the death activator CED-4 and the antiapoptotic protein CED-9, the authors explain the regulation of activity of CED-4. Intriguingly, CED-4 comprises a AAA+ type ATPase domain yet does not seem to need ATP hydrolysis for activity.
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