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  • Title: Dose proportionality study of loperamide following oral administration of loperamide oxide.
    Author: Kamali F, Adriaens L, Huang ML, Woestenborghs R, Emanuel M, Rawlins MD.
    Journal: Eur J Clin Pharmacol; 1992; 42(6):693-4. PubMed ID: 1623916.
    Abstract:
    The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
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