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  • Title: Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications.
    Author: Anandarajah AP, Schwarz EM.
    Journal: J Cell Biochem; 2006 Feb 01; 97(2):226-32. PubMed ID: 16240334.
    Abstract:
    Focal bone loss around inflamed joints in patients with autoimmune disease, such as rheumatoid arthritis, remains a serious clinical problem. The recent elucidation of the RANK/RANK-ligand/OPG pathway and its role as the final effector of osteoclastogenesis and bone resorption has brought a tremendous understanding of the pathophysiology of inflammatory bone loss, and has heightened expectation of a novel intervention. Here, we review the etiology of inflammatory bone loss, the RANK/RANK-ligand/OPG pathway, and the clinical development of anti-RANK-ligand therapy.
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