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Title: Micromechanical mass sensors for biomolecular detection in a physiological environment. Author: Braun T, Barwich V, Ghatkesar MK, Bredekamp AH, Gerber C, Hegner M, Lang HP. Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2005 Sep; 72(3 Pt 1):031907. PubMed ID: 16241482. Abstract: Micromechanical cantilever arrays are used to measure time-resolved adsorption of tiny masses based on protein-ligand interactions. Here, streptavidin-biotin interactions are investigated in a physiological environment. A measurement method is introduced using higher flexural modes of a silicon cantilever in order to enhance the sensitivity of mass detection. Modeling the cantilever vibration in liquid allows the measurement of absolute mass changes. We show time-resolved mass adsorption of final 7+/-0.7 ng biotinylated latex beads. The sensitivity obtained is about 2.5 pg/Hz measuring at a center frequency of 750 kHz.[Abstract] [Full Text] [Related] [New Search]