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  • Title: Clinical and immune responses correlate in glatiramer acetate therapy of multiple sclerosis.
    Author: Weder C, Baltariu GM, Wyler KA, Gober HJ, Lienert C, Schluep M, Radü EW, De Libero G, Kappos L, Duda PW.
    Journal: Eur J Neurol; 2005 Nov; 12(11):869-78. PubMed ID: 16241976.
    Abstract:
    Glatiramer acetate (GA) treatment for relapsing remitting multiple sclerosis (RRMS) leads to decreased GA-specific proliferative responses and a Th2 cytokine shift. To study a possible correlation between immunological and clinical responses to GA therapy, we prospectively followed RRMS patients clinically, by magnetic resonance imaging and by primary immunological assays. Fluctuation of GA-specific proliferative responses was significantly lower in treatment responders than in untreated patients, and GA-specific proliferative responses were increased during relapses. These associations suggest a possible causal relationship between immunological and clinical responses to GA therapy. Primary proliferation assays may thus be a useful marker for treatment response.
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