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  • Title: Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.
    Author: Pereira R, Gaudon C, Iglesias B, Germain P, Gronemeyer H, de Lera AR.
    Journal: Bioorg Med Chem Lett; 2006 Jan 01; 16(1):49-54. PubMed ID: 16242326.
    Abstract:
    Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARbeta/delta agonist yet described, and equally selective analogs at the thiazole-C4 position.
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