These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors.
    Author: Chahboune N, Barrachina I, Royo I, Romero V, Sáez J, Tormo JR, De Pedro N, Estornell E, Zafra-Polo MC, Peláez F, Cortes D.
    Journal: Bioorg Med Chem; 2006 Feb 15; 14(4):1089-94. PubMed ID: 16242335.
    Abstract:
    The antitumoral activity of a series of acetylated bis-tetrahydrofuranic acetogenins with a threo/trans/threo/trans/erythro relative configuration was characterized by four new natural and two semisynthetic, 15,24,30-trioxygenated acetogenins that were found to inhibit mitochondrial complex I enzyme as well as growth of several tumor cell lines. Placement of acetyl groups along the alkyl chain modulated the potency of the bis-tetrahydrofuranic acetogenins and could be important for future utilization of these compounds as chemotherapeutic agents.
    [Abstract] [Full Text] [Related] [New Search]