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  • Title: Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge.
    Author: Au WY, Kwong YL.
    Journal: J Am Acad Dermatol; 2005 Nov; 53(5):890-2. PubMed ID: 16243151.
    Abstract:
    In 44 patients treated with arsenic trioxide (As2(O3)) for acute promyelocytic leukemia, 11 developed varicella zoster virus (VZV) reactivation (median 56 days [range 15-299]) after treatment. There was no preferential dermatome involvement or systemic spread. The actuarial risk of VZV reactivation at 1 year was 26%. No VZV reactivation occurred after the first year of initial treatment with As2(O3).
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