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  • Title: Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease.
    Author: Bolo-Deoku J, Basu S, Lakhani S, Dunne F, Ratcliffe WA, Clarke M, Barron JL.
    Journal: J Clin Pathol; 1992 Jun; 45(6):541-2. PubMed ID: 1624608.
    Abstract:
    The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient.
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