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  • Title: Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors.
    Author: Wen X, Zhang P, Liu J, Zhang L, Wu X, Ni P, Sun H.
    Journal: Bioorg Med Chem Lett; 2006 Feb; 16(3):722-6. PubMed ID: 16246555.
    Abstract:
    The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC(50)=7 microM) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed.
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