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  • Title: Recent findings in immunology give tuberculosis vaccines a new boost.
    Author: Kaufmann SH.
    Journal: Trends Immunol; 2005 Dec; 26(12):660-7. PubMed ID: 16246622.
    Abstract:
    Tuberculosis remains a major health threat, solved by neither chemotherapy nor the current vaccine, BCG. Although a new generation of vaccine candidates is ready for field trials, further improvements will be required. A successful vaccination regime must stimulate memory T cells and, at the same time, avoid exhaustion of memory and suppression by regulatory mechanisms. The most probable scenario is priming with one vaccine candidate followed by boosting with a another vaccine candidate. For clinical trials, biomarkers need to be defined with T cells alternating between lung and periphery as prime indicator cells.
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