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  • Title: 2'-bis-pyrene modified oligonucleotides: sensitive fluorescent probes of nucleic acids structure.
    Author: Novopashina DS, Stetsenko DA, Totskaya OS, Repkova MN, Venyaminova AG.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2005; 24(5-7):729-34. PubMed ID: 16248025.
    Abstract:
    A new type of fluorescent nucleic acid probes, 2-bis-pyrene-modified oligonucleotides, is described. Preparation of these conjugates involves attachment of two pyrene moieties to the 2'-phosphate group introduced into any position within a sequence by solid-phase phosphoramidite synthesis. Good hybridization properties of the 2'-bis-pyrene probes, their nuclease resistance and sensitivity of fluorescence to the type of complementary nucleic acid have been demonstrated.
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