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  • Title: "Lock-in" modified cyclosal nucleotides--the second generation of cyclosal prodrugs.
    Author: Vukadinović D, Böge NP, Balzarini J, Meier C.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2005; 24(5-7):939-42. PubMed ID: 16248067.
    Abstract:
    A new generation of cycloSal-pronucleotides is presented. CycloSal-d4TMPs have been modified by introduction of an esterase-cleavable site in order to trap them inside cells. Hydrolysis studies in different media (PBS, CEM/0- and liver extracts) and anti-HIV evaluation of separated diastereomers revealed unexpected differences between the isomers.
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