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  • Title: Presence of 2',5'-linkages in a homopyrimidine DNA oligonucleotide promotes stable triplex formation under physiological conditions.
    Author: Obika S, Hiroto A, Nakagawa O, Imanishi T.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2005; 24(5-7):1055-8. PubMed ID: 16248091.
    Abstract:
    We prepared 15-mer homopyrimidine oligonucleotides containing three or four 2',5'-linked DNA units, and their ability as a triplex-forming oligonucleotide (TFO) was analyzed in detail UV melting experiments showed that replacement of a 3',5'-linkage by a 2',5'-linkage at every third or fourth residue in TFO significantly promoted stable triplex formation under physiological conditions.
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