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  • Title: Anti-HIV and cytotoxic alkaloids from Buchenavia capitata.
    Author: Beutler JA, Cardellina JH, McMahon JB, Boyd MR, Cragg GM.
    Journal: J Nat Prod; 1992 Feb; 55(2):207-13. PubMed ID: 1624941.
    Abstract:
    The anti-HIV activity in the organic solvent extract of leaves of Buchenavia capitata was traced to a series of known flavonoid alkaloids, which represent a new chemotype for anti-HIV activity. The 13C-nmr assignments for this series of compounds have been revised. O-Demethylbuchenavianine [1] was the most active compound of the series but produced only moderate cytoprotective effects against HIV in cultured human lymphoblastoid (CEM-SS) cells. Compound 1 was cytotoxic also in the NCI human disease-oriented in vitro tumor screening panel and produced a pattern of modest differential cellular sensitivity.
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