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  • Title: Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis.
    Author: Kirkpatrick WR, Vallor AC, McAtee RK, Ryder NS, Fothergill AW, Rinaldi MG, Patterson TF.
    Journal: Antimicrob Agents Chemother; 2005 Nov; 49(11):4751-3. PubMed ID: 16251321.
    Abstract:
    Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.
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