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  • Title: Fluoride dose response in pH-cycling models using bovine enamel.
    Author: Vieira AE, Delbem AC, Sassaki KT, Rodrigues E, Cury JA, Cunha RF.
    Journal: Caries Res; 2005; 39(6):514-20. PubMed ID: 16251798.
    Abstract:
    The aim of this study was to establish methodologies for verification of the fluoride solution dose-response relationship using bovine enamel and pH-cycling models. Six models of the cariogenic challenge were performed, varying the time of demineralization and pH, time of remineralization, composition of de- and remineralization solutions, frequency and time of application of treatment solutions and pH-cycling duration. For the evaluation of the fluoride effect on caries dynamics, two proposed models provided for improvement in standardization of methods leading to a higher level of precision, demonstrating a dose response between treatments with regard to surface microhardness and DeltaZ. For the evaluation of the fluoride effect on enamel remineralization, the addition of fluoride to the de- and remineralization solutions and the reduction of frequency and time of application of fluoride solutions led to a more suitable pH-cycling model.
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