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  • Title: [Progress on genetic susceptibility to ankylosing spondylitis].
    Author: Chen RW, Wang Y, Sun SH, Duan SW.
    Journal: Yi Chuan Xue Bao; 2005 Oct; 32(10):1108-14. PubMed ID: 16252708.
    Abstract:
    Ankylosing spondylitis (AS) is a highly heritable, common inflammatory rheumatic disease. Since 1970s, evidence has increasingly pointed to HLA-B27 as the major gene involved in susceptibility to AS. However, genome-wide scan and association studies have shown, in addition to HLA, regions outside the HLA are involved in susceptibility to AS. Furthermore, there is compelling evidence that non-B27 genes, either within or outside the HLA, are involved in disease aetiology. This review mainly summarized different genes associated with AS, and the current progress in this exciting area.
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