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  • Title: Halogenated helianane derivatives from the sponge Spirastrella hartmani.
    Author: Martín MJ, Berrué F, Amade P, Fernández R, Francesch A, Reyes F, Cuevas C.
    Journal: J Nat Prod; 2005 Oct; 68(10):1554-5. PubMed ID: 16252925.
    Abstract:
    Two new halogenated derivatives (1 and 2) of helianane (3) were isolated from the 2-propanol extract of the sponge Spirastrella hartmani. The structures of the new derivatives were determined on the basis of detailed spectroscopic analysis, including (+)-HREIMS and 1D and 2D NMR. Compound 1 showed in vitro cytotoxicity against the human tumor cell lines A549, HT29, and MDA-MB-231.
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