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  • Title: Comparison of cardiac troponin I levels in serum and sodium-citrate plasma using the ACCESS 2 immunoassay.
    Author: Wang YS, Feng CF, Er TK, Tsai LY, Chen CY, Chang SJ, Chen BH.
    Journal: Ann Clin Lab Sci; 2005; 35(4):453-4. PubMed ID: 16254264.
    Abstract:
    The aim of this study was to determine if sodium-citrate plasma is a suitable substitute for serum for cardiac troponin I (cTnI) measurement using the Beckman ACCESS 2 immunoassay. Linear regression analysis of cTnI levels in paired serum and sodium-citrate plasma samples from 80 patients provided a y-intercept of -0.0193 and a slope of 1.044. The correlation was good [r=0.995; 95% confidence interval 1.017 to 1.068, p <0.0001]. The paired results were not significantly different by Student's t-test. Serum and sodium-citrate plasma appear to be interchangeable as samples for cTnI measurement using the ACCESS 2 assay. Furthermore, the use of plasma reduces the turnaround time and may avoid false positive cTnI results due to residual fibrin.
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