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  • Title: Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine.
    Author: Gatch MB.
    Journal: Brain Res; 2005 Nov 16; 1062(1-2):161-5. PubMed ID: 16256082.
    Abstract:
    Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT(1/2) receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.
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