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  • Title: In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis.
    Author: Hallin E, Mellergård J, Vrethem M, Ernerudh J, Ekerfelt C.
    Journal: J Neuroimmunol; 2006 Feb; 171(1-2):156-62. PubMed ID: 16256209.
    Abstract:
    This study aimed at investigating if selective ex vivo immune deviation of myelin-specific cytokine secretion towards Th2 is possible in blood cells from patients with multiple sclerosis (MS). Interleukin (IL)-4 (Th2) and interferon-gamma (Th1) secreting cells were recorded by ELISPOT in 13 MS patients. Deviation was successful in 10 patients. Interleukin-4 alone was most effective in inducing myelin-specific immune deviation in MS patients whereas IL-1 or IL-15 in combination with IL-4 did not improve the results. Further studies and improvements are needed before ex vivo immune deviation can be considered a potential treatment in patients with MS.
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