These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tubulin nitration in human gliomas.
    Author: Fiore G, Di Cristo C, Monti G, Amoresano A, Columbano L, Pucci P, Cioffi FA, Di Cosmo A, Palumbo A, d'Ischia M.
    Journal: Neurosci Lett; 2006 Feb 06; 394(1):57-62. PubMed ID: 16257120.
    Abstract:
    Immunohistochemical and biochemical investigations showed that significant protein nitration occurs in human gliomas, especially in grade IV glioblastomas at the level of astrocytes and oligodendrocytes and neurones. Enhanced alpha-tubulin immunoreactivity was co-present in the same elements in the glioblastomas. Proteomic methodologies were employed to identify a nitrated protein band at 55 kDa as alpha-tubulin. Peptide mass fingerprinting procedures demonstrated that tubulin is nitrated at Tyr224 in grade IV tumour samples but is unmodified in grade I samples and in non-cancerous brain tissue. These results provide the first characterisation of endogenously nitrated tubulin from human tumour samples.
    [Abstract] [Full Text] [Related] [New Search]