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  • Title: Dexmedetomidine for awake craniotomy without laryngeal mask.
    Author: Almeida AN, Tavares C, Tibano A, Sasaki S, Murata KN, Marino R.
    Journal: Arq Neuropsiquiatr; 2005 Sep; 63(3B):748-50. PubMed ID: 16258649.
    Abstract:
    OBJECTIVE: This paper reports the use of dexmedetomidine in three epileptic patients with cavernous angiomas that underwent awake surgery in order to map their speech areas. METHOD: Loading dose of dexmedetomidine varied from 1 microg/Kg/h to 3 microg/Kg/h over 20 minutes and maintenance dose from 0.4 microg/Kg/h to 0.8 microg/Kg/h. RESULTS: There was no occurrence of hemodynamic instability, convulsions or respiratory depression. Patients tolerated well the procedure. CONCLUSION: Dexmedetomidine was useful for awake craniotomy as it decreased patients level of consciousness but did not produce agitation. Laryngeal mask was not necessary to keep air ventilation.
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