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  • Title: Risk factors for early death after liver resection in patients with solitary hepatocellular carcinoma.
    Author: Kondo K, Chijiiwa K, Makino I, Kai M, Maehara N, Ohuchida J, Naganuma S.
    Journal: J Hepatobiliary Pancreat Surg; 2005; 12(5):399-404. PubMed ID: 16258809.
    Abstract:
    BACKGROUND/PURPOSE: Although most patients who receive hepatectomy for a solitary hepatocellular carcinoma (HCC) have a relatively fair result, some have a poor prognosis. The aim of this study was to evaluate the risk factors for early death after hepatectomy in patients with a solitary HCC. METHODS: Eligible patients (n=110) who had undergone hepatectomy for solitary HCC between 1990 and 2002 and were able to be followed up for more than 2 years after the hepatectomy were divided into two groups, those who died of cancer recurrence within 2 years (early-death group; n=18) and those who survived for more than 2 years after the surgery (survival group; n=92). Risk factors for early death after liver resection were evaluated by univariate and multivariate analyses. RESULTS: The gross tumor classification, tumor diameter, macroscopic portal vein invasion, microscopic growth pattern, microscopic vascular invasion (MVI), and the width of the surgical margin were significant (P<0.05) factors by univariate analysis. Multivariate analysis showed that the presence of MVI was an independent and significant risk factor for early death of recurrence. CONCLUSIONS: Among patients with solitary HCC, the presence of MVI indicates a poor prognosis. These patients need adjuvant chemotherapy in the early period after hepatectomy.
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