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  • Title: What's New in HIV/AIDS? Chemokine receptor antagonists: a new era of HIV therapy?
    Author: Jülg B, Goebel FD.
    Journal: Infection; 2005 Oct; 33(5-6):408-10. PubMed ID: 16258879.
    Abstract:
    Chemokine receptors are essential for human immunodeficiency virus (HIV) cell entry. CXCR4 and CCR5 are the two most relevant receptors and by inhibition of each of them a delayed onset of disease could be achieved. As both receptors are used at different stages of disease due to the domination of different HIV strains, a dual blockage of CXCR4 and CCR5 could be highly valuable for inhibiting viral transmission and replication.
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