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  • Title: New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta.
    Author: Zhang CY, Wang X, Su T, Ma CM, Wen YJ, Shang MY, Li XM, Liu GX, Cai SQ.
    Journal: Pharmazie; 2005 Oct; 60(10):785-8. PubMed ID: 16259129.
    Abstract:
    Two novel phenanthrene derivatives, aristololactam IVa (1) and 9-hydroxy aristolochic acid I (2) were isolated from the stem and leaves of Anstolochia contorta Bunge, together with 17 known compounds (3-19). The structures of these compounds were determined by spectroscopic analysis. The phenanthrenes obtained were tested for cytotoxicity against renal proximal tubular epithelial cell line (HK-2). Aristololactam IVa and 7-methoxy aristololactam IV were found to have strong cytotoxic activity against HK-2 cells with a potency similar to or even stronger than those of aristolochic acid I and aristololactam I.
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