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  • Title: Precise hit: adeno-associated virus in gene targeting.
    Author: Vasileva A, Jessberger R.
    Journal: Nat Rev Microbiol; 2005 Nov; 3(11):837-47. PubMed ID: 16261169.
    Abstract:
    Vectors based on the adeno-associated virus (AAV) have attracted much attention as potent gene-delivery vehicles, mainly because of the persistence of this non-pathogenic virus in the host cell and its sustainable therapeutic gene expression. However, virus infection can be accompanied by potentially mutagenic random vector integration into the genome. A novel approach to AAV-mediated gene therapy based on gene targeting through homologous recombination allows efficient, high-fidelity, non-mutagenic gene repair in a host cell.
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