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  • Title: Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease.
    Author: Meier A, Mollenhauer B, Cohrs S, Rodenbeck A, Jordan W, Meller J, Otto M.
    Journal: Brain Res; 2005 Nov 30; 1063(2):201-3. PubMed ID: 16263095.
    Abstract:
    A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD.
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