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  • Title: Synthesis and biological activity of N,N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives.
    Author: Braña MF, Gradillas A, Ovalles AG, López B, Acero N, Llinares F, Muñoz Mingarro D.
    Journal: Bioorg Med Chem; 2006 Jan 01; 14(1):9-16. PubMed ID: 16263294.
    Abstract:
    New compounds, structurally related to the potent protein kinase C inhibitor staurosporine, with a bisindolylpyrazolone framework and substituted on the pyrazolone nitrogens with N,N-dialkylaminoalkyl side chain, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. Many showed inhibition of TNF-alpha production in response to the tumor promotor TPA on HL-60 cells. The apoptotic activity on HeLa cells has been examined for several of these compounds.
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