These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Fetomaternal signal transduction by growth factors].
    Author: Briese V, Müller H.
    Journal: Zentralbl Gynakol; 1992; 114(5):219-23. PubMed ID: 1626434.
    Abstract:
    An attempt was made to review the current knowledge on the role of growth factors in the field of fetomaternal interaction. Of special interest was the relation between maternal T-lymphocytes and fetal growth. Stimulation of cytotrophoblast growth is effected by: IGF I/II (insulin-like growth factor), CSF-1 (colony stimulating factor), EGF (epidermal growth factor), FGF (fibroblast growth factor), IL-1, IL-3 (Interleukin), PDGF (platelet derived growth factor). TNF (tumor necrosis factor) inhibits trophoblast cell growth. TNF is synthesized in both decidual and chronic cells. CSF-1 considered the most potent stimulator of the induction of trophoblast cell growth. Cytotrophoblast itself produces IGF I/II, EGF, PDGF, TGF (transforming growth factor). Furthermore, it is known that HCG-secretion is mainly stimulated by IL-1. Whereas intra- and paracrine mechanisms in the placenta will remain in the field of basic research for the next future, animal experiments proving the positive impact of IL-3 and GM-CSF (granulocyte/macrophage-colony stimulating factor) on trophoblast growth should give reason for clinical investigations. It is assumed, that maternal T-lymphocytes realize paternally inherited alloantigenic structures resulting in local response of IL-3 and GM-CSF production.
    [Abstract] [Full Text] [Related] [New Search]