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  • Title: Design, synthesis, and biological evaluation of simplified analogues of (+)-discodermolide. Additional insights on the importance of the diene, the C7 hydroxyl, and the lactone.
    Author: Smith AB, Xian M.
    Journal: Org Lett; 2005 Nov 10; 7(23):5229-32. PubMed ID: 16268545.
    Abstract:
    [structure: see text] The design, synthesis, and biological evaluation of seven totally synthetic analogues of the antitumor agent (+)-discodermolide are reported. Saturation of the terminal diene system, alteration of the substituents on the lactone, and alkylation of the C7-hydroxyl group reveal significant structure-activity relationships.
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