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  • Title: A concise approach to 2-azabicyclo[3.3.1]nonane derivatives from an acyclic precursor.
    Author: Aurrecoechea JM, Gorgojo JM, Saornil C.
    Journal: J Org Chem; 2005 Nov 11; 70(23):9640-3. PubMed ID: 16268651.
    Abstract:
    [Reaction: see text]. Condensation of a readily available 5-amino-2-alkenoate ester with alpha-unsubstituted aliphatic aldehydes leads to substituted 1,2,3,4-tetrahydropyridines. Subsequent manipulation of the ester and enamine functions gives a quick access to 2-azabicyclo[3.3.1]nonane-containing compounds.
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