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  • Title: Association of the carboxy-terminus of beta-amyloid protein precursor with Alzheimer paired helical filaments.
    Author: Caputo CB, Sobel IR, Scott CW, Brunner WF, Barth PT, Blowers DP.
    Journal: Biochem Biophys Res Commun; 1992 Jun 30; 185(3):1034-40. PubMed ID: 1627127.
    Abstract:
    We investigated whether a peptide fragment from the C-terminus of beta-amyloid protein precursor is associated with Alzheimer paired helical filaments (PHFs). Antiserum BR188, to the last 20 amino acids of the precursor, did not cross-react with tau protein, known to be in PHFs. It did react with all five pronase-treated PHF preparations assayed by ELISA and immunogold-labelled the same PHF fibrils that a PHF-specific tau antibody labelled. Neither antibody labelled beta/A4 fibrils. These results suggest that a fragment from the C-terminus of beta-amyloid precursor protein copurifies with pronase-treated PHFs and may play a role in their molecular pathogenesis.
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