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  • Title: Protein-tyrosine kinase p72syk is activated by wheat germ agglutinin in platelets.
    Author: Ohta S, Taniguchi T, Asahi M, Kato Y, Nakagawara G, Yamamura H.
    Journal: Biochem Biophys Res Commun; 1992 Jun 30; 185(3):1128-32. PubMed ID: 1627134.
    Abstract:
    We previously reported a molecular cloning of porcine gene syk encoding a non-receptor type 72-kDa protein-tyrosine kinase (Taniguchi et al. (1991) J. Biol. Chem. 266, 15790-15796). In this study, we have demonstrated that p72syk is expressed in porcine platelets at 0.1-0.2% of total protein and that the lectin wheat germ agglutinin induces an activation of p72syk against both auto- and exogenous-substrate-phosphorylation in porcine platelets. The activation of p72syk was abrogated by the coexistence of N-acetyl-D-glucosamine with wheat germ agglutinin. These data suggest that p72syk is a candidate of responsible protein-tyrosine kinase for platelet activation and that cell surface glycoprotein is involved in the activation of p72syk in platelets.
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