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  • Title: [Apoptosis: a possible mechanism of suppressing parathyroid hyperplasia by calcimimetics].
    Author: Mizobuchi M, Saji F, Shiizaki K, Sato T, Shibata M, Negi S, Akizawa T, Hatamura I, Ogata H, Kinugasa E.
    Journal: Clin Calcium; 2005 Sep; 15 Suppl 1():56-8; discussion 58-9. PubMed ID: 16272631.
    Abstract:
    The mechanism through which calcimimetic compounds suppress parathyroid cell growth has not been fully elucidated. We investigated the effect of the calcimimetic compound (NPS R-568:R568) on the parathyroid cell growth in vitro. Whole parathyroid glands of subtotally nephrectomized rats fed high phosphorus diet for 8 weeks were used in this study. Fresh rat parathyroid glands were incubated in a media (phosphorus concentration is 1.0 mM and calcium is 1.25 mM) with R-568 (10-4 M) or calcitriol (10-7 M) or vehicle for 6 hours. Medium PTH level was significantly decreased in both R568-treated group and calcitriol-treated group compared with either vehicle-treated group, or no-treated group. While TUNEL-positive cells were similar in calcitriol-treated group compared with both vehicle-treated and no-treated groups, they were significantly increased in R568-treated group compared with other three groups. These results suggest that calcimimetic compounds, NPS R-568 reduces PTH secretion and induces apoptosis of hyperfunctional parathyroid cell in vitro.
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