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  • Title: [High prevalence of secondary hyperparathyroidism due to vitamin D insufficiency in Graves' disease].
    Author: Doi Y, Yamashita H, Noguchi S.
    Journal: Clin Calcium; 2005 Sep; 15 Suppl 1():68-70; discussion 70. PubMed ID: 16272633.
    Abstract:
    We studied concentrations of serum calcium, intact parathyroid hormone (iPTH), and 25 hydroxyvitamin D (25 [OH] D) in 343 patients with Graves' disease (273 women, 70 men) during one year period. The serum 25 (OH) D levels were 37+/-19 nmol/L and vitamin D deficiency (defined as a serum 25 (OH) D value below 25 nmol/L) was found in 35% of the patients. There was a significant seasonal variation in the 25 (OH) D concentrations, with high values of 51+/-21 nmol/L during the summer term (July-September), and with low values of 26+/-17 nmol/L during the winter term (January-March). The average serum iPTH level was 48+/-26 pg/mL, with 26% (89/343) having values above the normal range. Our results showed high prevalence of secondary hyperparathyroidism in patients with Graves' disease during antithyroid drug therapy and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency.
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