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  • Title: Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.
    Author: Veazey RS, Springer MS, Marx PA, Dufour J, Klasse PJ, Moore JP.
    Journal: Nat Med; 2005 Dec; 11(12):1293-4. PubMed ID: 16273102.
    Abstract:
    Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
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