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  • Title: Predicting spike times of a detailed conductance-based neuron model driven by stochastic spike arrival.
    Author: Jolivet R, Gerstner W.
    Journal: J Physiol Paris; 2004; 98(4-6):442-51. PubMed ID: 16274972.
    Abstract:
    Reduced models of neuronal activity such as integrate-and-fire models allow a description of neuronal dynamics in simple, intuitive terms and are easy to simulate numerically. We present a method to fit an integrate-and-fire-type model of neuronal activity, namely a modified version of the spike response model, to a detailed Hodgkin-Huxley-type neuron model driven by stochastic spike arrival. In the Hogkin-Huxley model, spike arrival at the synapse is modeled by a change of synaptic conductance. For such conductance spike input, more than 70% of the postsynaptic action potentials can be predicted with the correct timing by the integrate-and-fire-type model. The modified spike response model is based upon a linearized theory of conductance-driven integrate-and-fire neurons.
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