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  • Title: Comparison of transforming growth factor-beta/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions.
    Author: Tsujita-Kyutoku M, Uehara N, Matsuoka Y, Kyutoku S, Ogawa Y, Tsubura A.
    Journal: In Vivo; 2005; 19(6):959-63. PubMed ID: 16277007.
    Abstract:
    BACKGROUND: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. MATERIALS AND METHODS: Fibroblasts were isolated from the central and peripheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. RESULTS: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-beta) receptor 1 and Smad 2/3. CONCLUSION: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-beta/Smad pathway.
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