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  • Title: Neuroleptic malignant syndrome and preexisting brain damage.
    Author: Lazarus A.
    Journal: J Neuropsychiatry Clin Neurosci; 1992; 4(2):185-7. PubMed ID: 1627980.
    Abstract:
    A case of neuroleptic malignant syndrome (NMS) is described in a congenitally brain-damaged deaf patient. The literature suggests that NMS in patients with organic brain syndrome is induced by a reduction of marginal stores of dopamine in the hypothalamus and basal ganglia resulting from dopamine-blocking activity of neuroleptics, even at conventionally low doses. Brain-damaged patients should be recognized as being at higher risk of developing NMS.
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