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  • Title: Synthesis and anti-HCMV activity of novel 5'-norcarboacyclic nucleosides.
    Author: Kim A, Hong JH.
    Journal: Arch Pharm (Weinheim); 2005 Nov; 338(11):522-7. PubMed ID: 16281312.
    Abstract:
    A very simple route for synthesizing a novel carboacyclic version of 5 cent-noraristeromycin is described. Condensation of the mesylates 9 and 23 with the natural nucleosidic bases (A, U, T, C) under standard nucleophilic substitution (K(2)CO(3), 18-Crown-6, DMF) and deblocking conditions, afforded the target nucleosides 14, 15, 16, 17, 28, 29, 30, and 31. In addition, these compounds were evaluated for their antiviral properties against various viruses.
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