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  • Title: [Efficacy of tegafur/uracil plus oral leucovorin therapy for advanced or recurrent colorectal cancer].
    Author: Kabashima A, Sakaguchi Y, Okita K, Yamamura S, Ojima Y, Nishizaki T, Tashiro H, Matsuzaka T.
    Journal: Gan To Kagaku Ryoho; 2005 Nov; 32(12):1935-8. PubMed ID: 16282730.
    Abstract:
    The aim of this study was to evaluate the efficacy of tegafur/uracil (UFT) and oral Leucovorin(UZEL) in patients with advanced or recurrent colorectal cancer. Eight patients were treated with UFT/UZEL therapy as a first-line chemotherapy. UFT(300 mg/m(2)/day) and UZEL (75 mg/body/day) were administered orally for 28 consecutive days followed by a 7-day rest period, and this schedule was repeated every 5 weeks. The mean of treatment courses given to the patients was 7.6. Tumor response was evaluated in 7 patients who had assessable lesions, and the response rate was 86% (6 PR and 1 NC). Adverse reactions of grade 3 were observed in 2 patients (25%), but toxicity did not cause a discontinuance of treatment in any case. The UFT/UZEL therapy was considered to be a promising regimen for advanced or recurrent colorectal cancer from a standpoint of effect, safety and QOL of patients.
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