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  • Title: Regulatory role of Na,K-ATPase in the growth of heart tissue explants in organotypic culture.
    Author: Lopatina EV, Penniyainen VA, Zaika AA.
    Journal: Bull Exp Biol Med; 2005 Aug; 140(2):184-6. PubMed ID: 16282996.
    Abstract:
    We studied the effects of ouabain, norepinephrine, and acetylcholine on the growth of heart tissue explants from 10-12-old chicken embryos in an organotypic culture. Ouabain, norepinephrine, and acetylcholine stimulated the growth of explants. Our results suggest that trophic function of acetylcholine and norepinephrine is associated with regulation of Na,K-ATPase activity as a signal transducer.
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