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  • Title: Ruthenium-catalyzed cycloaddition of alkynes and organic azides.
    Author: Zhang L, Chen X, Xue P, Sun HH, Williams ID, Sharpless KB, Fokin VV, Jia G.
    Journal: J Am Chem Soc; 2005 Nov 23; 127(46):15998-9. PubMed ID: 16287266.
    Abstract:
    Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.
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