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  • Title: The interaction between ICOS and B7RP-1 is not required for the development of experimental murine allergic conjunctivitis.
    Author: Fukushima A, Yamaguchi T, Ishida W, Fukata K, Yagita H, Ueno H.
    Journal: Biochem Biophys Res Commun; 2005 Dec 30; 338(4):1726-31. PubMed ID: 16289109.
    Abstract:
    It is still unclear whether the interaction between inducible costimulator (ICOS) and its ligand, B7 related protein (B7RP)-1, is important for the development of allergic diseases. We investigated whether blocking the ICOS/B7RP-1 interaction affects the development of murine experimental allergic conjunctivitis (EC). EC was induced in Balb/c mice either by active immunization of ragweed (RW) or by transferring RW-primed splenocytes, followed by challenge with RW-containing eye drops. The mice were treated with anti-B7RP-1 antibody (Ab) or normal rat immunoglobulin G (IgG) during either the induction or effector phase. Regardless of the induction method or when the animals were treated, eosinophil infiltration into the conjunctiva was not affected by the anti-B7RP-1 Ab treatment. Splenocyte responses were not largely affected by this treatment. However, serum Ig levels were significantly reduced. These data suggest that blocking the ICOS/B7RP-1 in allergic diseases may not always be therapeutic.
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