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  • Title: Drug discovery and sea hares: bigger is better.
    Author: Barsby T.
    Journal: Trends Biotechnol; 2006 Jan; 24(1):1-3. PubMed ID: 16290235.
    Abstract:
    Traditionally, small molecules (<1kDa) have dominated the study of the chemistry and chemical ecology of marine natural products. However, as reported in a recent publication, Yang and co-workers have isolated a 60-kDa antibacterial protein from the defensive secretions of the sea hare Aplysia californica. This protein, escapin, has been characterized as an l-amino acid oxidase with bacteriostatic and bacteriocidal activities. Their work highlights the largely untapped biomedical potential of marine organism-derived proteins and addresses the problems of supply associated with invertebrate natural products. It also leads to intriguing hypotheses about the ecological function(s) of the new protein.
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