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  • Title: Case study: psychiatric misdiagnosis of non-24-hours sleep-wake schedule disorder resolved by melatonin.
    Author: Dagan Y, Ayalon L.
    Journal: J Am Acad Child Adolesc Psychiatry; 2005 Dec; 44(12):1271-5. PubMed ID: 16292119.
    Abstract:
    This case study describes a 14-year-old male suffering from significant academic and personal difficulties, who has been diagnosed with depression, schizotypal personality disorder, and learning disabilities. Because of excessive sleepiness, assessment for a potential sleep disorder was performed. An overnight polysomnographic study revealed no primary sleep disorders. Wrist actigraphy revealed a non-24-hour sleep-wake pattern. Delay in temperature rhythm and dissociation with melatonin rhythms were also noted. Treatment with oral melatonin restored normal sleep-wake schedule. In a follow-up psychiatric evaluation, none of the above diagnoses were present. Greater awareness of sleep disorders may prevent psychiatric misdiagnosis of treatable sleep-wake schedule disorders.
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