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  • Title: Severe systemic hypersensitivity reaction to ibuprofen: a presentation of systemic lupus erythematosus.
    Author: Mou SS, Punaro L, Antón J, Luckett PM.
    Journal: J Rheumatol; 2006 Jan; 33(1):171-2. PubMed ID: 16292790.
    Abstract:
    We describe the first severe systemic hypersensitivity reaction to ibuprofen in a pediatric patient with previously undiagnosed systemic lupus erythematosus (SLE). An 11-year-old Thai male presented with fever, rash, altered mental status, and hypotension after oral administration of ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted in recurrence of presenting symptoms. Severe hypersensitivity with hypotension can be a rare consequence of the use of ibuprofen in children with collagen vascular disease. When encountered in an otherwise healthy child, a high index of suspicion must be maintained for the diagnosis of SLE.
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